Background: Vitreous Hemorrhage secondary to proliferative diabetic retinopathy is a cause of severe vision loss in diabetic patients. The surgical approach in vitreous hemorrhage (VH) secondary to diabetic retinopathy remains the procedure of choice for non-clearing vitreous hemorrhage. Objective: To compare the visual outcome and associated factors between groups of patients who underwent immediate and delayed vitrectomy for the management of vitreous hemorrhage due to proliferative diabetic retinopathy (PDR). Methods: This Quasi study of 40 patients who underwent vitrectomy in one eye for vitreous hemorrhage Secondary to Proliferative Diabetic Retinopathy (PDR). Patients were excluded if they had prior vitrectomy, or vitreous hemorrhage due to other causes (vascular occlusion, uveitis, advanced glaucoma. Every patient received Intravitreal Anti VEGF 3-7 days prior to the vitrectomy. Primary outcome was observed visual acuity in the patient receiving immediate (less than 40 days) versus delayed (more than 40 days) vitrectomy. Result: 40 eyes were included, 15 eyes had immediate vitrectomy while 25 eyes had delayed vitrectomy. There was no difference between the groups in terms of age, gender; diabetes control. But the duration of diabetes had an important role in visual acuity of those patients. During diabetes more than 10 years had poor vision and most of them are in delayed vitrectomy group. Pre-operative and final visual acuity were evaluated including 7 days, 30 days, and 4 months in both groups. Immediate vitrectomy shows good visual outcomes. Complications (re-bleeding) were dominantly seen in the delayed vitrectomy group. Conclusion: Immediate vitrectomy for Vitreous hemorrhage due to PDR can save vision and decrease post-surgical complication in diabetic patients. Vitrectomy with Endo laser surgery is safe and may be considered earlier vitreous hemorrhage management.