For the treatment of corneal ectasias such as keratoconus, corneal collagen cross-linking (CXL) using
riboflavin and ultraviolet A irradiation has recently been developed. Intraocular pressure (IOP)
measurements may be affected by an increase in corneal stiffness brought on by CXL. Our research
sought to ascertain if corneal collagen crosslinking with UVA and riboflavin would have an impact on
intraocular pressure readings using Goldmann applanation tonometry (GAT). The investigation was
conducted at the Ispahani Islamia Eye Institute and Hospital's cornea department in Dhaka. In this
study, 31 eyes from 30 patients receiving CXL treatment because to keratoconus were enrolled. All of
the patients had a thorough ocular examination at the time of their initial registration. IOP measured
one month, three months, and six months following CXL using Goldmann applanation tonometry.
Thirty patients were included, of which over one third (36.7%) were under the age of fifteen. The age
ranged from 11 to 27 years old, with a mean of 18.0±4.4 years. The majority was male (86.7%). The
gender ratio was 6.5 to 1. The intraocular pressure was 10.03±2.09 mmHg prior to CXL, 11.23±1.86
mmHg in the first month following CXL, 12.42±1.86 mmHg in the third month following CXL, and
12.94±1.98 mmHg in the sixth month following CXL. When compared to before CXL, the mean
intraocular pressure increased at the one-month, three-month, and six-month marks. These increases
were statistically significant (p<0.05). In eyes with keratoconus, riboflavin-UVA CXL resulted in a
substantial increase in intraocular pressure as determined by GAT. This increase was likely caused by
an increase in corneal stiffness. This suggests that routinely measuring IOP may be a reliable and
significant predictor of rising corneal resistance, which is the primary objective of CXL treatment.